SRG Rat, Sprague Dawley-Rag2em2heraIl2rgem1hera/HblCrl
The SRG (Sprague Dawley, Rag2, Il2rg- "SRG") is a severely immunodeficient inbred rat created through knockout mutations in the Rag2 and Il2rgamma genes, resulting in a deficiency in mature B, T, and NK cells. This severe immunodeficiency, combined with a larger organism size, makes the SRG rat an ideal alternative research model to mice in certain preclinical applications.
Nomenclature: Sprague Dawley-Rag2em2heraIl2rgem1hera/HblCrl
Type: Inbred rat, genetically engineered, immunodeficient
Origin: The SRG rat was transferred from Transposagen to Hera Biolabs in 2016. To Charles River from Hera Biolabs in 2021.
Coat color: White
Strain code: 707
Ideal for:Tumor biology, oncology, immunology, xenograft transplant research
Bred in: Germany, US
Health reports: Go to Charles River website here
*Photos provided courtesy of Charles River