Charles River Laboratories

ZDF rat (Lean +/?) and (Lean fa/+), ZDF-Leprfa/Crl

Code ZDF rat, lean

Control model for ZDF Rat (Obese fa/fa).

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Cardiovascular Metabolism Obesity, overweight

Features

Nomenclature: ZDF-Lepr^fa/Crl

Type: Inbred

Origin: A mutation occurred in a colony of outbred Zucker rats in the laboratory of Dr. Walter Shaw at Eli Lilly Research Laboratories in Indianapolis, IN in 1974–75. Part of this colony containing the mutation was moved to Indiana University Medical School (IUMS), to the laboratory of Dr. Julia Clark in 1977. Several groups of animals with diabetic lineage were identified and rederived in 1981. Inbreeding of selected pairs from this rederivation was done in the laboratory of Dr. Richard Peterson at IUMS. An inbred line of ZDF rat was established in 1985. To Genetic Models, Inc. in 1991. To Charles River in 2001.

Coat color: Black hooded with black stripe down the length of the back

Strain codes: 371 (Lean +/?) or 380 (Lean fa/+)

Ideal for: Controls for the ZDF Rat (Obese fa/fa).

Bred in: France, US

Health reports: Using strain nomenclature find the strain at links below

*Photos provided courtesy of Charles River