ADME

bcrp rat
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Homozygous knockout BCRP with an increased exposure to BCRPspecific substrates. For applications of drug metabolism research, pharmacodynamics and pharmacokinetics, drug-drug interactions.
bdnf rat alzheimers 4
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Knockout the gene encoding the ABC transporter, a critical in exporting pump bile salts.
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Knockout model encoding CAR having effects on induction of cytochrome p450s. It has applications in the study of hepatotoxicity, cholestasis and drug metabolism.
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The model has the deleted gene organic anion transporter 3 OAT3. Useful in clinical drug-drug interactions, toxicity and liver metabolism.
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Knockout model to study the role of nuclear receptors in the impact of carcinogenic substances, the compounds of xenobiotic metabolism and hepatotoxicity.