Operant Behavior System

Operant Behaviour System

Operant Behavior System


TSE Operant Behavior Systems are fully computerized Skinner boxes built from a wide choice of individual components that are easily mounted into the base construction.

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  • Description
  • Publications

Operant Behavior System

TSE Operant Behavior Systems are fully computerized Skinner boxes built from a wide choice of individual components that are easily mounted into the base construction. Each Skinner box is a completely self-contained unit in a sound and light-attenuating fan-ventilated housing suitable for all standard operant tasks.

Box control and data acquisition are made easy with the comprehensive TSE Operant Behavior software package. Run one of the preprogrammed schedules which are continuously being further developed according to the latest research applications. Alternatively individually designed schedules can be created employing our unique and easy-to-learn free programming language.

Special box configurations allow learned helplessness or drug self-administration experiments to be performed.

Operant Behavior tasks can also be performed with the new TSE PhenoMaster research platform – this comprehensive phenotyping system allows operant behavior studies under stress-free conditions in a home cage environment (for more details, see the operant learning module Operant Wall)

Key features

  • Versatile modular boxes for rats & mice
  • Standard, weight-adjustable, illuminated or retractable levers or nose-poke response modules
  • Single and triple cue lamps
  • Choice of food and liquid reinforcers incl. intravenous self-administration configuration. The pellets are available in sizes of 14/ 20/ 45 mg (mice 14mg, rats 20/45mg).
  • Standard rewarding schedules: FR, VR, PR, FI, VI, PI, DRH and DRL, Geller conflict, drug discrimination
  • Integrated flexible program editor for user-defined protocols


Lesion of the medial prefrontal cortex and the subthalamic nucleus selectively affect depression-like behavior in rats

Klein J, Winter C, Coquery N, Heinz A, Morgenstern R, Kupsch A, Juckel G
Behav Brain Res 2010; 213:73-81
VideoMot, Operant Behavior System



A common genetic predisposition to stress sensitivity and stress-induced nicotine craving

Bilkei-Gorzo A, Rácz I, Michel K, Darvas M, Maldonado R, Zimmer A
Biol Psychiatry 2008; 63(2):164-71
VideoMot, ActiMot, Startle Response, Operant Behavior System

The chakragati mouse shows deficits in prepulse inhibition of acoustic startle and latent inhibition

Verma V, Tan CH, Ong WY, Grigoryan GA, Jones CA, Stolzberg D, Salvi R, Gross KW, Ratty AK, Dawe GS
Neurosci Res 2008; 60:281-288
Operant Behavior System



Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1Brdm1 mutant mice

Zghoul T, Abarca C, Sanchis-Segura C, Albrecht U, Schumann G, Spanagel R
Psychopharmacology 2007; 190:13-9
Operant Behavior System



A novel bivalent morphine/heroin vaccine that prevents relapse to heroin addiction in rodents

Anton B, Leff P
Vaccine 2006; 24:3232-40
Operant Behavior System

Clomipramine and selegiline: do they influence impulse control?

Bert B, Harms S, Langen B, Fink H
J Vet Pharmacol Therap 2006; 29(1):41-7
Operant Behavior System

Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse

Sanchis-Segura C, Borchardt T, Vengeliene V, Zghoul T, Bachteler D, Gass P, Sprengel R, Spanagel R
J Neurosci 2006; 26(4):1231-8
Operant Behavior System

A proteomics approach to identify long-term molecular changes in rat medial prefrontal cortex resulting from sucrose self-administration

Van den Oever MC, Spijker S, Li KW, Jimenez CR, Koya E, Van der Schors RC, Gouwenberg Y, Binnekade R, De Vries TJ, Schoffelmeer AN, Smit AB
J Proteome Res 2006; 5:147-54
Operant Behavior System



Early age-related cognitive impairment in mice lacking cannabinoid CB1 receptors

Bilkei-Gorzo A, Racz I, Valverde O, Otto M, Michel K, Sarstre M, Zimmer A
PNAS 2005; 102(43):15670-5
ActiMot, Operant Behavior System

Role of the pedunculopontine tegmental nucleus in sensorimotor gating and reward-related behavior in rats

Diederich K, Koch M
Psychopharmacology 2005; 179:402-8
Startle Response, Operant Behavior System, ActiMot

Effects of the cannabinoid receptor agonist win 55,212-2 on operant behavior and locomotor activity in rats

Drews E, Schneider M, Koch M
Pharmacol Biochem Behav 2005; 80:145-50
ActiMot, Operant Behavior System

Reduced sensitivity to sucrose in rats bred for helplessness: a study using the matching law

Sanchis-Segura C, Spanagel R, Henn F, Vollmayr B
Behav Pharmacol 2005; 16:267-70
Operant Behavior System

Differential involvement of the prelimbic cortex and striatum in conditioned heroin and sucrose seeking following long-term extinction

Schmidt ED, Voorn P, Binnekade R, Schoffelmeer AN, De Vries TJ
Eur J Neurosci 2005; 22:2347-56
Operant Behavior System

Behavioral and morphological alterations following neonatal excitotoxic lesions of the medial prefrontal cortex in rats

Schneider M, Koch M
Exp Neurol 2005; 195:185-98
ActiMot, Operant Behavior System, Stereotaxic Instruments, Startle Response

Behavioral effects in adult rats of chronic prepubertal treatment with the cannabinoid receptor agonist WIN 55,212-2

Schneider M, Drews E, Koch M
Behav Pharmacol 2005; 16:447-53
ActiMot, Operant Behavior System, Startle Response

Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases

Siegmund S, Vengeliene V, Singer MV, Spanagel R
Alcohol Clin Exp Res 2005; 29(7):1139-45
Operant Behavior System, Drinking / Feeding

The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption

Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U
Nat Med 2005; 11(1):35-42
Operant Behavior System



Reduced sensitivity to reward in CB1 knockout mice

Sanchis-Segura C, Cline BH, Marsicano G, Lutz B, Spanagel R
Psychopharmacology 2004; 176(2):223-32
Operant Behavior System



A behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus

Ruettiger L, Ciuffani J, Zenner HP, Knipper M
Hear Res 2003; 180:39-50
Operant Behavior System

Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats

Schneider M, Koch M
Neuropsychopharmacology 2003; 28:1760-9
Startle Response, Operant Behavior System, ActiMot

A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake

Vengeliene V, Siegmund S, Singer MV, Sinclair JD, Li TK, Spanagel R
Alcohol Clin Exp Res 2003; 27(7):1048-54
Operant Behavior System, Drinking / Feeding

Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness

Vollmayr B, Simonis C, Weber Silja, Gass P, Henn F
Biol Psychiatry 2003; 54:1035-40
Operant Behavior System



The cannabinoid agonist WIN 55,212-2 reduces sensorimotor gating and recognition memory in rats

Schneider M, Koch M
Behav Pharmacol 2002; 13:29-37
Startle Response, Operant Behavior System



Lack of reinforcing effect of the benzodiazepine and tricyclic antidepressant combination of diazepam and dothiepin

Oittinen H, Rameis H, Saria A, Zernig G
Pharmacology 2001; 62:124-8
Operant Behavior System

Reinforcing effects of MDMA („Ecstasy”) in drug-naive and cocaine-trained rats

Ratzenboeck E, Saria A, Kriechbaum N, Zernig G
Pharmacology 2001; 62:138-44
Operant Behavior System

Brain-derived- neurotrophic-factor (BDNF) stress response in rats bred for learned helplessness

Vollmayr B, Faust H, Lewicka S, Henn FA
Mol Psychiatry 2001; 6:471-4
Operant Behavior System

Learned helplessness in the rat: improvements in validity and reliability

Vollmayr B, Henn FA
Brain Res Mol Brain Res 2001; 8:1-7
Operant Behavior System



Role of nucleus accumbens dopamine D1 and D2 receptors in instrumental and Pavlovian paradigms of conditioned reward

Koch M, Schmid A, Schnitzler HU
Psychopharmacology 2000; 152:67-73
Operant Behavior System



Temporal analysis of feeding behavior in miniature pigs

Musial F, Kowalski A, Kalveram KT, Enck P
Dtsch Tierarztl Wochenschr 1998; 105(12):456-60
Operant Behavior System