Sutter Instrument
IPA® / DOUBLE IPA® Integrated Patch Clamp Amplifiers with Data Acquisition System
Code IPA / IPA-2
The IPA® and Double IPA® are Sutter Instrument's integrated patch clamp amplifiers enabling efficient, low-noise whole-cell recordings. Available in single- (IPA®) or dual-headstage (Double IPA®) configurations, with bundled SutterPatch® software.
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Features
IPA® / Double IPA® — Integrated Patch Clamp Amplifiers
The IPA® family of Integrated Patch Clamp Amplifiers from Sutter Instrument enables efficient, low-noise whole-cell recordings. Available as a single-headstage (IPA®) or dual-headstage (Double IPA®) system, the IPA combines state-of-the-art amplifier technology with fully integrated D/A and A/D conversion and a high-speed USB interface. Acquisition, data management, and streamlined analysis are performed using the bundled SutterPatch® software, built on the foundation of Igor Pro (WaveMetrics).
Amplifier
- Voltage clamp and true current clamp modes with smart switching to avoid current artifacts
- FastFollower™ current clamp and fully integrated dynamic clamp capability
- Open-circuit (RMS) noise of 1.4 pA in 0.1–10 kHz bandwidth
- Pipette capacitance compensation up to 25 pF; whole-cell compensation: Cm 1–100 pF, Rs 1–100 MΩ
- Four-pole Bessel low-pass filter (0.5–20 kHz)
- Full computer control — automated compensation of electrode and whole-cell capacitance
- Series resistance prediction and correction (0–100 MΩ)
Data Acquisition
- Embedded DAQ system — no external digitizer needed
- Single high-speed USB connection controls DAQ and amplifier
- Up to 8 input channels (0.1–50 kHz sampling rate per channel); up to 400 kHz aggregate
- Multi-amplifier mode: connect up to two IPA/Double IPA units for up to 16 input channels
- 4 auxiliary analog input channels (±10 V); 2 analog output channels; 8 digital (TTL) outputs
- Standard "octopus" breakout cable; optional Patch Panel for tidy front-rack I/O
SutterPatch® Software
- Real-time analysis: I-V curves, time course plots, up to 8 simultaneous real-time graphs
- Event Detection Module, Action Potential Analysis Module, Camera Module
- Waveform Editor; 2D and 3D scope display; Data Navigator; Solution Editor
- Over 500 metadata attributes; publication-quality graphics
- Windows 10 or later (64-bit) or macOS 10.11 or later
Applications of IPA® / Double IPA® System
- Tissue slice recordings
- Cultured-cell experiments
- Cell line studies from adherent or dispersed cells
- In-vivo patch clamp
- Network studies
- Optogenetics
Specifications
- Headstage configurations: IPA® (single) / Double IPA® (dual)
- RMS noise (0.1–10 kHz): 1.4 pA
- Low-pass filter: 4-pole Bessel, 0.5–20 kHz
- Analog inputs (aux): 4 (±10 V)
- Analog outputs: 2 (±10 V)
- Digital outputs: 8 (TTL)
- Aggregate sampling rate: up to 400 kHz
- Multi-amplifier mode: up to 2 units / up to 16 input channels
- USB: High Speed USB 2.0
- Dimensions (IPA®): 48 cm × 30 cm × 4.5 cm
- Dimensions (Double IPA®): 48 cm × 30 cm × 9 cm
- Dimensions (Headstage): 10 cm × 3.5 cm × 1.9 cm
- Dimensions (Patch Panel): 48 cm × 5 cm × 9 cm
- Weight (IPA®): 4 kg
- Weight (Double IPA®): 3.7 kg
- Weight (Patch Panel): 1.6 kg
- Electrical: 110/240 V, 50/60 Hz
- OS: Windows 10 (64-bit) or later; macOS 10.11 or later
Components
Standard system components
- IPA IPA system with headstage, EH-P170 pipette holder, model cell, octopus breakout cable, rack mounting hardware, SutterPatch® software suite with Igor Pro® license
- IPA-2 Double IPA system with two headstages, two EH-P170 pipette holders, model cell, octopus breakout cable, rack mounting hardware, SutterPatch® software suite with Igor Pro® license
Publications
- Dolzer J (2021): Patch Clamp Technology in the Twenty-First Century. In: Dallas M., Bell D. (eds) Patch Clamp Electrophysiology. Methods in Molecular Biology, vol 2188. Humana, New York, NY. doi:10.1007/978-1-0716-0818-0_2
- Experiments of interest involving Sutter Instrument amplifier systems and SutterPatch® software. PDF list of publications