Charles River Laboratories

SCID Hairless Congenic (SHC) mouse, CB17.Cg-PrkdcscidHrhr/IcrCrl

Code SHC

Congenic hairless mice exhibit the severe combined immunodeficiency phenotype.

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Immunology Oncology, cancer

Features

Nomenclature: CB17.Cg-Prkdc^scidHr^hr/IcrCrl

Type: Congenic, Immunodeficient

Cryopreserved

Origin: The hairless SCID congenic was created in 2009 by Charles River Research Models by using marker-assisted accelerated backcrossing to place the hairless gene (Hr^hr) present in the Crl:SKH1-Hr^hr stock onto a CB17/Icr-Prkdc^scid/IcrIcoCr genetic background. These mice are homozygous for both Hr^hr and Prkdc^scid mutations, so exhibit the severe combined immunodeficiency phenotype characteristic of SCID mice and are also hairless.

See Charles River webpage with resources about immunodeficient models: Immunodeficient Mice and Rats

Coat color: Hairless, albino background

MHC Haplotype: H2^d

Strain code: 488

Ideal for: Tumor biology and xenograft research

Bred in: US

Health reports: Using strain nomenclature find the strain at links below