The immunodeficient NSG mice enable research in human immune function, infectious disease, diabetes, oncology, and stem cell biology.
Nomenclature: NOD.Cg-Prkdcscid Il2rgtm1WjI/SzJ
Type: Immunodeficient, Inbred
Origin: Developed by Dr. Lenny Shultz at The Jackson Laboratory, the JAX™ Mice strain NOD.Cg-PrkdcscidIl2rgtm1Wjl/SzJ (005557) is commonly known as the NOD scid gamma (NSG®). It is a mutant mouse which combines the features of the NOD/ShiLtJ background (conferring a number of deficiencies in innate immunity), the severe combined immune deficiency mutation (scid) and an IL2 receptor gamma chain deficiency which disables cytokine signalling. As a result, the NSG® mice lack mature T cells, B cells, functional NK cells, and are also deficient in cytokine signaling. NSG® mice do not suffer from scid leakiness and their resistance to lymphoma leads to a much longer lifespan than NOD.CB17-Prkdcscid/J mice. Introduction from The Jackson Laboratory in 2009 followed by scheduled replacement of the pedigreed breeding stock according to The Jackson's Genetic Quality Management System.
See Charles River webpage with resources about immunodeficient models: Immunodeficient Mice and Rats
Coat color: White (albino)
Strain code: 614
Ideal for: Oncology, immunology, virology research, xenograft/transplant host (outstanding utility in the studies of islet transplantation, hematopoietic stem cells and cancer stem cells)
JAX™ Stock No: 005557
More information about the strain:
Note: Only The Jackson Laboratory and Charles River in Europe and Japan maintain colonies of JAX™ Mice strains which are derived from pedigreed mice from The Jackson Laboratory and are re-infused routinely with pedigreed mice to stabilise the genetic integrity and phenotype of these strains.
JAX™ is a trademark of The Jackson Laboratory registered in the United States. All rights reserved.
Charles River Laboratories is the official distributor of JAX mice in Europe. Click and read more.
Bred in: Germany, France, Italy, UK
Health reports: Using strain nomenclature find the strain at links below
- animals health reports bred in Charles River Germany
- animals health reports bred in Charles River France
- animals health reports bred in Charles River Italy
- animals health reports bred in Charles River UK
*Photos provided courtesy of Charles River