Active Avoidance Set-Up (Shuttle-Box)

Active Avoidance Set-Up (Shuttle-Box)


The new model of Active Avoidance Set-Up has been designed to enable the researcher to perform a wide range of avoidance experiments, each ac-cording to a flexible schedule.

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  • Description
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Active Avoidance Set-Up (Shuttle-Box)

Active Avoidance Set-Up 
(Automatic Reflex Conditioner)

  • Cat. No. 40532 Rats    
  • Cat. No. 40533 Mice

The new model of Active Avoidance Set-Up has been designed to enable the researcher to perform a wide range of avoidance experiments, each ac-cording to a flexible schedule.
Via the TIMELINE feature, the user will be able to configure a number of different tests, according to the specific experimental needs, namely the classi-cal shuttle-box tests in its various modes.
Ugo Basile Active Avoidance set-up instrument ba-sically consists of a Controller, and a Cage for either rat or mouse. 
The tests are conducted in a cage, divided into two sections by a partition with an intercommunicating opening at floor level. 
The tilting floor ensures a simple and reliable detec-tion mechanism to score the animalʼs movement across the two compartments.
The electronic unit encompasses all controls for up to 4 cages, and a scrambling shocker.

Main Features

  • Maximum flexibility: configure your own Avoidance-Experiment Schedules via the timeline function
  • The electronic unit encompasses all con-trols for up to 4 animal cages!
  • Reliable tilting-floor detection mechanism

Instrument Description 

Different set-ups, depending on animal (rat or mouse) and number of cages, can be obtained by combining the following elements:

  • Programming/Recording Unit with Shocker
  • lRat Cage (up to 4 with one controller)


  • Mouse Cage  (up to 4 with one controller)
  • Expansion Box, for multiple cage set-up

Programming/Recording Unit

The 40500-001 Programming/Recording Unit, encom-passing all controls, incorporates a constant-current high precision 8-pole shocker, and manages data acqui-sition: data are stored inside the unit and can be down-loaded via the USB key provided as standard, for further processing via Excel, Access, etc. The Unit, incorporating a 12” touch-screen, manages the Passive Avoidance Test via the 40530-010 Software. Up to 4 cages can be connected to the same Controller.

If more than one cage is connected, an expansion box 40500-005 is required for each additional cage.
The trials can be configured via the TIMELINE feature, entering the setting via the virtual keyboard: trial num-ber, the acoustic/visual stimulus, delay, shock intensity, and timing of the different experimental sequences:


Active-Avoidance Cage (shuttle-box)
Two types of cages are available: 

  • 40532 designed for Rats
    dimensioned 57x27x30(h)cm, I.D. 48x20x22(h)cm
  • 40533 designed for Mice
    dimensioned 47x18x25(h)cm, I.D. 38x9x17(h)cm
  • D. Dimitrova, D. Getova: “Effects of Rivastigmine on Learning and Memory Processes in Rats Active Avoi-dance Test” Medicine 4.1, 2014
  • G.N. Carmona et alia: “The Dense Core Vesicle Protein IA-2, but not IA-2β, is Required for Active Avoidance Learning” Neuroscience 269 (6): 35-42, 2014
  •  O. Ortiz et alia: “Associative Learning and CA3‒CA1 Synaptic Plasticity Are Impaired in D1R Null, Drd1a/Mice and in Hippocampal siRNA Silenced Drd1a Mice“ J. Neuroscience 30 (37): 12288-12300, 2010 
  • J.I. Lemos et alia: “Involvement of the prelimbic pre-frontacortex on cannabidiol-induced attenuation of contextual conditioned fear in rats“ Behav. Brain Res. 207: 05-111, 2010
  • N. Seferos et alia: “Mandibular bone density and cal-cium content affected by different kind of stress in mice“ J Musculoske
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Passive Avoidance Test is used to assess memory function based on the association formed between a specific environmental context, which the animal  learns to avoid, and an aversive stimulus, represen-ted by a mild foot shock.
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The Passive Avoidance step-down cage, for mice or immature rats, is based on the stepdown scheme in which the animal is dropped on an elevated platform which becomes uncomfortable because of vibrations.